EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.3 | expression of splice variant AKR1D1 in HEK-293 cell | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.3 | Homo sapiens | P51857 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.3 | liver | splice variants AKR1D1-002 and AKR1D1-001 are expressed in liver | Homo sapiens | - |
1.3.1.3 | testis | only splice variant AKR1D1-006 is expressed in testis | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.3 | dexamethasone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | ? + NADP+ | - |
? | |
1.3.1.3 | additional information | splice variant AKR1D1-002 efficiently metabolizes glucocorticoids and androgens and decreases receptor activation. Variants AKR1D1-001 and AKR1D1-006 poorly metabolize dexamethasone, but do not metabolize cortisol, prednisolone, testosterone or androstenedione | Homo sapiens | ? | - |
- |
|
1.3.1.3 | prednisolone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | ? + NADP+ | - |
? | |
1.3.1.3 | testosterone + NADPH + H+ | substrate of splice variant AKR1D1-002 | Homo sapiens | (5beta,17beta)-17-hydroxyandrostan-3-one + NADP+ | - |
? |
EC Number | Organism | Comment | Expression |
---|---|---|---|
1.3.1.3 | Homo sapiens | treatment of cells with proteasomal inhibitor, MG-132 increases expression of splice variants AKR1D1-001 and AKR1D1-006 | up |